Washington Refuses To Fund Building Of ?Death Star?

The office of the US President has rejected a popular public petition to construct a Death Star due to a high construction cost of $850 quadrillion, a major design flaw and the fact that ?the Administration does not support blowing up planets.?

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The proposal to construct the Star Wars-inspired space station-cum-death ray was lodged in November last year through We the People, a recently-implemented system that allows ordinary Americans to petition the government with any request, providing it gets enough popular support.

The authors promised that building the Death Star would ?spur job creation in the fields of construction, engineering, space exploration, and more, and strengthen our national defense.?

The petition has collected 34,435 signatures, well above the 25,000 threshold that necessitates a response from the White House.

But despite endorsement from the public, the government has been reluctant to make the necessary investment in the pioneering space platform.

Titled ?This Isn?t the Petition Response You?re Looking For? and authored by Paul Shawcross, who oversees science and space departments at the White House, the official response gives three reasons for why the project isn?t viable:

? The construction of the Death Star has been estimated to cost more than $850,000,000,000,000,000. We?re working hard to reduce the deficit, not expand it.

? The Administration does not support blowing up planets.

? Why would we spend countless taxpayer dollars on a Death Star with a fundamental flaw that can be exploited by a one-man starship?

Instead, Shawcross calls for Americans to revel in the existence of the rather more modest International Space Station, which although impressive, does not possess a death ray, or in fact weapons of any sort.

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This is not the only time We the People has been used to push forward unlikely proposals. Recent petitions have called for British TV interviewer Piers Morgan to be deported for his gun control stance (more than 100,000 signatures) for Texas to secede (more than 120,000 signatories) and to recount the presidential election, which 68,000 petitioners claim Barack Obama won through a combination of fraud and administrative error.

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Source: http://www.secretsofthefed.com/washington-refuses-to-fund-buildng-of-death-star/

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Live from the Engadget CES Stage: the Engadget Podcast CES closer (update: video embedded)

Hoooooooo-boy. We did it, guys! The craziest week of the year is finally over. It's time for a little R&R -- well, once we've spoken to our entire staff about the CES that is. We're tired, we're loopy and we're in it to win it. You're not gonna want to miss this one, kids.

January 10, 2013 11:00 PM EST

Check out our full CES 2013 stage schedule here!

Update: video embedded

Continue reading Live from the Engadget CES Stage: the Engadget Podcast CES closer (update: video embedded)

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Source: http://www.engadget.com/2013/01/11/engadget-podcast/

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Video: The real star of the Academy Awards: Washington, D.C.

Irreconcilable differences: Kelly and Kelly Hildebrandt end marriage

??Kelly Hildebrandt is no longer married to Kelly Hildebrandt. Nope, that is not a typo. The same-name couple whose whirlwind, heart-warming romance drew headlines in the United States and abroad has divorced, the male Hildebrandt, Kelly Carl Hildebrandt, told NBC 6 on Friday.

Source: http://video.msnbc.msn.com/hardball/50437494/

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Report: Lance to admit doping in Oprah interview

AUSTIN, Texas (AP) ? Lance Armstrong plans to admit to doping throughout his career during an upcoming interview with Oprah Winfrey, USA Today reported late Friday.

The interview, scheduled to be taped Monday and broadcast Thursday night on the Oprah Winfrey Network, will be conducted at Armstrong's home in Austin, Texas.

Citing an anonymous source, USA Today reported that the disgraced cyclist plans to admit using performance-enhancing drugs, but likely will not get into details of the allegations outlined in a 2012 report by the U.S. Anti-Doping Agency that led to Armstrong being stripped of his seven Tour de France titles and banned for life from the sport.

His representatives declined comment late Friday, including attorney Tim Herman, but Armstrong sent a text to the Associated Press early Saturday morning saying: "I told her (Winfrey) to go wherever she wants and I'll answer the questions directly, honestly, candidly. That's all I can say."

The New York Times first reported last week that Armstrong was considering making a confession.

The 41-year-old Armstrong, who vehemently denied doping for years, has not spoken publicly about the USADA report that cast him as the leader of a sophisticated and brazen doping program on his U.S. Postal Service teams that included use of steroids, blood boosters and illegal blood transfusions.

Winfrey's network announced Tuesday that Armstrong agreed to a "no holds barred" interview with her.

A confession to Winfrey would come at a time when some of Armstrong's legal troubles appear to be clearing up.

Any potential perjury charges stemming from his sworn testimony denying doping in a 2005 arbitration fight with a Dallas promotions company over a contract bonus worth $7.5 million have passed the statute of limitations.

Armstrong faces a whistle-blower lawsuit filed by former teammate Floyd Landis accusing him of defrauding the U.S. Postal Service, but the U.S. Department of Justice has yet to announce if it will join the case. The British newspaper The Sunday Times is suing Armstrong to recover about $500,000 it paid him to settle a libel lawsuit.

Armstrong lost most of his personal sponsorship ? worth tens of millions of dollars ? after USADA issued its report and he left the board of the Livestrong cancer-fighting charity he founded in 1997. He is still said to be worth an estimated $100 million.

Livestrong might be one reason to issue an apology or make a confession. The charity supports cancer patients and still faces an image problem because of its association with its famous founder.

The New York Times reported that Armstrong may make a confession in an attempt to return to competition in elite triathlon or running events, but World Anti-Doping Code rules state his lifetime ban cannot be reduced to less than eight years. WADA and U.S. Anti-Doping officials could agree to reduce the ban further depending on what new information Armstrong provides and his level of cooperation.

Armstrong met with USADA officials recently to explore a "pathway to redemption," according to a report by "60 Minutes Sports" aired Wednesday on Showtime.

Source: http://news.yahoo.com/report-lance-admit-doping-oprah-interview-065926568--spt.html

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Note to Republicans: Please Keep Talking About Rape (Little green footballs)

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Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma

Friday, January 11, 2013

Think of the epigenome like a giant musical mixing board, turning up or down the expression of various genes. A University of Colorado Cancer Center study published today in the journal PLOS Genetics shows that in cancer, not only can genes themselves go bad, but abnormal changes in the epigenetic mixing board can unfortunately change the expression of these genes. Researchers hope to play the role of sound engineers, controlling these harmful epigenomic changes to turn down cancer itself or perhaps sensitize cancers to existing drugs.

The epigenome's primary tool ? and by far the easiest to study ? is methylation: it attaches little methyl groups to DNA sequences near the genes to silence or promote their expression.

"Not only do we see more abnormal methylation in non-Hodgkin lymphoma patients than in healthy B-cell populations, but there are three distinct subtypes of the disease in the clinic, each more aggressive than the next. These three clinical trajectories of non-Hodgkins lymphoma were distinctly marked by their levels of abnormal methylation," says Subhajyoti De, PhD, CU Cancer Center investigator and assistant professor at the CU School of Medicine.

In other words, methylation patterns predict patient survival. Here's how it works:

DNA should be methylated in a consistent way ? you get a certain, standardized amount of methyl "residue" attached to your genes. Sure enough, that's the case in healthy B-cells. Subhajyoti and colleagues show that in cancerous B-cells, the level of DNA methylation from cell to cell varies wildly. And the more wildly the level of DNA methylation varies, the more aggressive is the cancer. It's as if, in the body, you want a consistent epigenome that maintains the methylation of the healthy status quo ?when a willy-nilly epigenome drops methylation randomly here and there, it promotes non-normal cells, like cancer.

So abnormal methylation is certainly correlated with not only cancer, but with the aggressive behaviors of cancer subtypes. But what exactly is the functional role of this methylation?

"We think that in addition to genetic mutations that cause cancer, epigenetic changes probably play a subtle role that allows the cancer to thrive within our body," Subhajyoti says.

There are drugs that affect the epigenome's ability to methylate and so control genes ? some of which crescendo or decrescendo the amount of methylation across the board, and some of which affect the amount of methylation on certain genetic products. Does one of these drugs hold the key to muting cancer?

Subhajyoti hopes to find out.

"For the last 50 years, the scientific community pushed to identify the genetic drivers of cancer, but now in the past five or six years we've expanded the search into the epigenome as well," Subhajyoti says. "We now expect to find that both genetic and epigenetic abnormalities are important for initiation and maintenance of cancer."

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University of Colorado Denver: http://www.ucdenver.edu

Thanks to University of Colorado Denver for this article.

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Source: http://www.labspaces.net/126251/Epigenomic_abnormalities_predict_patient_survival_in_non_Hodgkins_lymphoma

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